Basic Information
| LncRNA/CircRNA Name | FOXCUT |
| Synonyms | FOXCUT, LINC01379, TCONS_00011636 |
| Region | GRCh38_6:1605531-1606079 |
| Ensemble | ENSG00000280916 |
| Refseq | NR_125804 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | ESCC tissues, cell lines (KYSE30, KYSE70, KYSE140, KYSE150, KYSE180 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Notably elevated FOXCUT and FOXC1 expression levels were observed in cancerous tissues compared to adjacent noncancerous tissues, showing strong correlations with poor differentiation, advanced lymph node classification and metastasis. The expression of FOXCUT was positively correlated with expression of FOXC1 in ESCC specimens. And the expression of FOXC1 was also decreased as the FOXCUT expression was silenced by siRNA. Assays in vitro demonstrated that knockdown of either FOXCUT or FOXC1 remarkably inhibited cell proliferation, colony formation, migration, invasion in ESCC cells. |
| Pubmed ID | 25031703 |
| Year | 2014 |
| Title | A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma. |
External Links
| Links for FOXCUT | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |