Basic Information
| LncRNA/CircRNA Name | FOXCUT |
| Synonyms | FOXCUT, LINC01379, TCONS_00011636 |
| Region | GRCh38_6:1605531-1606079 |
| Ensemble | ENSG00000280916 |
| Refseq | NR_125804 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | basal-like breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (MDA-MB-231, MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that the expression of FOXCUT and FOXC1 were positively correlated. When the expression of FOXCUT was downregulated by small interfering RNA, the expression of FOXC1 was similarly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, knockdown of FOXCUT markedly inhibited cell proliferation and migration in vitro. In conclusion, FOXCUT lncRNA may be functionally involved in the tumor progression of BLBCs through the regulation of its paired mRNA, FOXC1, demonstrating that FOXCUT may serve as a novel biomarker and therapeutic target in BLBCs. |
| Pubmed ID | 25516208 |
| Year | 2014 |
| Title | Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer. |
External Links
| Links for FOXCUT | GenBank HGNC NONCODE |
| Links for basal-like breast cancer | OMIM COSMIC |