Basic Information
| LncRNA/CircRNA Name | FOXC2-AS1 |
| Synonyms | FOXC2-AS1, ODRUL |
| Region | GRCh38_16:86565145-86567761 |
| Ensemble | ENSG00000260944 |
| Refseq | NR_125795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell line (MCF-10A, MDA-MB-468, MDA-MB-231, MDA-MB-436, MCF-7), BC tissue |
| Expression Pattern | up-regulated |
| Function Description | Cyclin D1 Cyclin D2, and Cyclin D3 were all partly positively modulated by FOXC2-AS1 in BC. FOXC2-AS1 may serve as a promising prognostic biomarker and therapeutic target for BC patients. FOXC2-AS1 significantly suppressed the proliferation ability and flow cytometric analysis illustrated the influence of FOXC2-AS1 on cell cycle and apoptosis rate. |
| Pubmed ID | 29562954 |
| Year | 2018 |
| Title | Long non-coding RNA FOXC2-AS1 predicts poor survival in breast cancer patients and promotes cell proliferation |
External Links
| Links for FOXC2-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |