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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, etc.
Sample	lung cancer tissues, Human bronchial epithelial cell line (16HBE) and human lung cancer cell lines (SPCA1, A549, and H1299)
Expression Pattern	up-regulated
Function Description	the expression of FLVCR1 AS1 was increased in lung cancer tissues according to The Cancer Genome Atlas database. Similarly, FLVCR1 AS1 was significantly upregulated in lung cancer cell lines. Knockdown of FLVCR1 AS1 dramatically reduced the cell proliferation, migration, and invasion of SPCA1 and A549. Mechanistically, we found that the expression levels of CTNNB1, SOX4, CCND1, CCND2, c MYC, as well as nucleus ? catenin were decreased in lung cancer cells after FLVCR1 AS1 silencing. Thus, FLVCR1 AS1 positively regulates the activation of the Wnt/? catenin pathway. Overexpression of CTNNB1 reversed the effect of FLVCR1 AS1 knockdown on A549 cells. In sum, FLVCR1 AS1 silencing inhibited the proliferation, migration, and invasion of lung cancer cells by inhibiting the activity of the Wnt/? catenin signaling pathway.
Pubmed ID	30697812
Year	2019
Title	lncRNA FLVCR1-AS1 silencing inhibits lung cancer cell proliferation, migration, and invasion by inhibiting the activity of the Wnt/?-catenin signaling pathway.

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