Basic Information
| LncRNA/CircRNA Name | FLVCR1-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:212852108-212858088 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Dual luciferase reporter assay, RIP |
| Sample | glioma tissues,Glioma cell lines and human astrocyte cell line (NHA) |
| Expression Pattern | up-regulated |
| Function Description | FLVCR1-AS1 was highly expressed in glioma tissues and cell lines. And upregulation of FLVCR1-AS1 predicted poor prognosis in patients with glioma. Moreover, FLVCR1-AS1 knockdown inhibited proliferation, migration and invasion of glioma cells. Through bioinformatics analysis, we identified that FLVCR1-AS1 was a sponge for miR-4731-5p to upregulate E2F2 expression. Moreover, rescue assays indicated that FLVCR1-AS1 modulated E2F2 expression to participate in glioma progression. |
| Pubmed ID | 31699367 |
| Year | 2020 |
| Title | Long Noncoding RNA FLVCR1-AS1 Aggravates Biological Behaviors of Glioma Cells via Targeting miR-4731-5p/E2F2 Axis |
External Links
| Links for FLVCR1-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |