Basic Information
| LncRNA/CircRNA Name | FGFR3-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, Western blot, in vitro knockdown |
| Sample | human liver cancer cell lines (SMMC-7721, BEL-7404 (7404), Huh7, Hep3B and HepG2 ) |
| Expression Pattern | up-regulated |
| Function Description | FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis.Moreover,FGFR3-AS1 knockdown led to more HCC cells arrested in G0 stage. Besides, FGFR3-AS1 knockdown significantly inhibited cell migration and invasion. Additionally,we found that FGFR3-AS1 silence dramatically delayed tumor growth in vivo.In mechanism, we found FGFR3-AS1 silence decreased the activation of PI3K/AKT signaling pathway.LncRNAs could regulate cell proliferation,apoptosis, migration and invasion by sponging miRNAs or interacting with specific proteins.Furthermore, western blot (WB) results indicated that FGFR3-AS1 knockdown promoted the expression of P21 but inhibited CYCLIN D1 expression. |
| Pubmed ID | 29463348 |
| Year | 2018 |
| Title | Long non-coding RNA FGFR3-AS1 promotes hepatocellular carcinoma carcinogenesis via modulating PI3K/AKT pathway. |
External Links
| Links for FGFR3-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |