Basic Information
| LncRNA/CircRNA Name | FGD5-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:14920347-14948424 |
| Ensemble | ENSG00000225733 |
| Refseq | NR_046251 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR, Western blot, Luciferase Reporter Assay |
| Sample | OSCC tissues,oral keratinocyte (HOK) and OSCC cells (HSC-4, SCC-25, CAL-27 and SCC-9) |
| Expression Pattern | up-regulated |
| Function Description | FGD5-AS1 expression was aberrantly up-regulated in OSCC tissue and cells. FDG5-AS1 up-regulation induced USP21 overexpression advances OSCC development. Knockdown of FGD5-AS1 inhibited cell growth, migration, and invasion, yet promoted apoptosis.FGD5-AS1 regulates OSCC via competitively binding to miR-520b against USP21. |
| Pubmed ID | 31899825 |
| Year | 2020 |
| Title | LncRNA FGD5-AS1 Can Be Predicted as Therapeutic Target in Oral Cancer |
External Links
| Links for FGD5-AS1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |