Basic Information
| LncRNA/CircRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 |
| Ensemble | ENSG00000230316 |
| Refseq | NR_036484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RNAi |
| Sample | gastric cancer tissues, cell lines (MGC-803, MKN-49P, BGC-823, SGC-7901, AGS,NCI-N87,GES-1) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA FEZF1-AS1 was observably upregulated in human GC tissues and GC cell lines.high expression of lncRNA FEZF1-AS1 was significantly associated with later stage and higher grade. lncRNA FEZF1-AS1 may be an independent prognostic factor in GC.whenever the lncRNA FEZF1-AS1 was silenced, the proliferation of GC cells were significantly inhibited and the cell cycle was arrested at a G0/G1 stage in GC cells.downregulation of lncRNA FEZF1-AS1 could suppress the activation of the Wnt/B-catenin signaling pathway. |
| Pubmed ID | 29239821 |
| Year | 2017 |
| Title | Long noncoding RNA FEZF1-AS1 indicates a poor prognosis of gastric cancer and promotes tumorigenesis via activation of Wnt signaling pathway. |
External Links
| Links for FEZF1-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |