Basic Information
| LncRNA/CircRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 |
| Ensemble | ENSG00000230316 |
| Refseq | NR_036484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (DLD-1, HT29, HCT116, SW480, SW620, Lovo) |
| Expression Pattern | up-regulated |
| Function Description | Here, we discovered a novel lncRNA FEZF1-AS1 is markedly upregulated in human primary CRC and associated with CRC metastasis and poor prognosis. Moreover, the downregulation of FEZF1-AS1 expression significantly inhibited the CRC cells proliferation, migration and invasiveness, suppressed S-phase entry in vitro, and repressed tumor growth and metastasis in vivo. In contrast, overexpression of FEZF1-AS1 could promote the aggressive behaviors of CRC cells. |
| Pubmed ID | 26848625 |
| Year | 2016 |
| Title | Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma. |
External Links
| Links for FEZF1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |