Basic Information
| LncRNA/CircRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 |
| Ensemble | ENSG00000230316 |
| Refseq | NR_036484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qRT-PCR etc. |
| Sample | retinoblastoma tissues and adjacent normal retina tissues ,human retinoblastoma cell lines (Weri-RB-1, Y79 and RBL-13) ,human retinal pigment epithelial cell line (ARPE-19) |
| Expression Pattern | up-regulated |
| Function Description | Levels of FEZF1-AS1 expression were elevated in retinoblastoma tissue specimens and cell lines compared with adjacent normal retina tissue specimens and human retinal pigment epithelial cell line, respectively.High FEZF1-AS1 expression was significantly correlated with present choroidal invasion and optic nerve invasion.Retinoblastoma patients in high FEZF1-AS1 expression group had obviously short disease-free survival (DFS) compared with retinoblastoma patients in low FEZF1-AS1 expression group, and high FEZF1-AS1 expression was an independent unfavorable prognostic factor for DFS in retinoblastoma patients.Silencing FEZF1-AS1 expression inhibited retinoblastoma cell proliferation,invasion and migration. |
| Pubmed ID | 31076545 |
| Year | 2019 |
| Title | FEZF1-AS1 functions as an oncogenic lncRNA in retinoblastoma |
External Links
| Links for FEZF1-AS1 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |