Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | EC tissues, cell lines (HEC-1 and HEC-50) |
| Expression Pattern | down-regulated |
| Function Description | FER1L4 showed significantly downregulation in EC tissues compared to control, which was positively correlated with decreased PTEN expression. Moreover, FER1L4 could promote PTEN expression and inhibit Akt phosphorylation. Additionally, a significant decrease of cell proliferation was observed in FER1L4 overexpressing cells, along with cell cycle arrest at G0/G1 phase and increased proportion of apoptotic cells. |
| Pubmed ID | 27381864 |
| Year | 2016 |
| Title | LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma. |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |