Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | colon cancer tissues, cell lines (NCM460, RKO, Lovo, HCT116, SW480 and SW620) |
| Expression Pattern | down-regulated |
| Function Description | The results showed the aberrant expression of FER1L4 and miR-106a-5p in colon cancer tissues. In addition, significant negative correlation between FER1L4 and miR-106a-5p expression levels was observed. Among the colon cancer cell lines, FER1L4 levels were relatively lower, with concurrent high levels of miR-106a-5p. Restoration of FER1L4 decreased the expression of miR-106a-5p, and had a significant influence on colon cancer cell proliferation, migration and invasion. The FER1L4 expression was correlated with depth of tumor invasion, lymph node metastasis, vascular invasion and clinical stage. Circulating FER1L4 and miR-106a-5p levels were decreased and increased, respectively, in colon cancer patients after surgery. |
| Pubmed ID | 26224446 |
| Year | 2015 |
| Title | Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer. |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |