Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Paclitaxel | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, other |
| Sample | Human ovarian epithelial cell lines IOSE80 and HOSEpiC and human ovarian carcinoma cell lines OVCAR-3, Caov-3, and SKOV3 |
| Expression Pattern | up-regulated |
| Function Description | The FER1L4 level was decreased in human ovarian cancer cells with drug resistance than in common ovarian cancer cells. The upregulation of FER1L4 could promote the PTX sensitivity of ovarian cancer cells. The increased level of FER1L4 could suppress the PTX resistance of ovarian cancer cells through the inhibition of the MAPK signaling pathway. |
| Pubmed ID | 30444026 |
| Year | 2018 |
| Title | Overexpression of the lncRNA FER1L4 Inhibits Paclitaxel Tolerance of Ovarian Cancer Cells via the Regulation of the MAPK Signaling Pathway |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |