Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | lung cancer tissues and adjacent normal tissues ,normal lung cell line BEAS-2B ,lung cancer cell lines( SPC-A-1, A549, H1975, H-125 and 95D) |
| Expression Pattern | down-regulated |
| Function Description | The expression level of FER1L4 was significantly decreased in clinical lung cancer tissues and in cultured lung cancer cells.Overexpression of FER1L4 in lung cancer cell lines A549 and 95D inhibited colony formation, cell proliferation and cell migration capacity,Overexpression of FER1L4 led to a reduction in the expression levels of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) in A549 and 95D cells, whereas, activation of PI3K/Akt signaling using a small molecular inhibitor of phosphatase and tensin homolog, reversed the inhibitory effects of FER1L4 on cell proliferation and metastasis. |
| Pubmed ID | 31115514 |
| Year | 2019 |
| Title | Long Non-coding RNA FER1L4 Inhibits Cell Proliferation and Metastasis Through Regulation of the PI3K/AKT Signaling Pathway in Lung Cancer Cells |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |