Basic Information
| LncRNA/CircRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 |
| Ensemble | ENSG00000088340 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | esophageal squamous cell cancer tissues, cell lines (Eca109, EC9706, KYSE30, KYSE150 and KYSE450) |
| Expression Pattern | down-regulated |
| Function Description | Compared with that in normal tissues, FER1L4 was lowly expressed in ESCC tissues. Overexpression of FER1L4 could inhibit cell proliferation and invasion, promote apoptosis and increase the cell cycle distribution in G0/G1 phase. Knockout of FER1L4 could promote the proliferation and invasion of ESCC cells, inhibit apoptosis and decrease the cell cycle distribution in G0/G1 phase. In conclusion, FER1L4, as a tumor suppressor lncRNA, is involved in the regulation of invasion and metastasis capacities of ESCC. |
| Pubmed ID | 29771417 |
| Year | 2018 |
| Title | LncRNA FER1L4 Suppressed Cancer Cell Growth and Invasion in Esophageal Squamous Cell Carcinoma |
External Links
| Links for FER1L4 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |