Basic Information
| LncRNA/CircRNA Name | FENDRR |
| Synonyms | FENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 |
| Region | GRCh38_16:86474529-86509099 |
| Ensemble | ENSG00000268388 |
| Refseq | NR_033925 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | doxorubicin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | osteosarcoma tissues, cell lines (MG63, SaoS2 and HOS) |
| Expression Pattern | down-regulated |
| Function Description | FENDRR expression was down-regulated in the doxorubicin-resistant OS cell lines and tissues and negatively correlated to the poor prognosis of OS patients. Together, our study demonstrated that lncRNA FENDRR may act as an inhibitory molecule of doxorubicin-resistance through down-regulating the expression of ABCB1 and ABCC1 genes in osteosarcoma cells. |
| Pubmed ID | 29069754 |
| Year | 2017 |
| Title | LncRNA FENDRR sensitizes doxorubicin-resistance of osteosarcoma cells through down-regulating ABCB1 and ABCC1 |
External Links
| Links for FENDRR | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |