Basic Information
| LncRNA/CircRNA Name | FENDRR |
| Synonyms | NA |
| Region | GRCh38_16:86474529-86509099 |
| Ensemble | ENSG00000268388 |
| Refseq | NR_033925 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Hepatocellular Carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | HCC cell lines, MHCC97, HCCLM3, HepG2, Hep3B, and Huh7, and human normal hepatic cell L02, HCC tissues and adjacent normal tissues |
| Expression Pattern | down-regulated |
| Function Description | lncRNA FENDRR competitively bound to microRNA-423-5p (miR-423-5p), and miR-423-5p specifically targeted growth arrest and DNA-damage-inducible beta protein (GADD45B). The effects that lncRNA FENDRR and miR-423-5p have on the cell proliferation and apoptosis, the immune capacity of regulatory T cells (Tregs), and the tumorigenicity of HCC cells were examined through overexpressing or the knocking down of lncRNA FENDRR and miR-423-5p both in vitro and in vivo. Subsequently, lncRNA FENDRR and GADD45B were revealed to have poor expressions in HCC. Meanwhile, miR-423-5p was highly expressed in HCC. Importantly, overexpressed lncRNA FENDRR and downregulated miR-423-5p diminished cell proliferation and tumorigenicity, and promoted apoptosis in HCC cells, thus regulating the immune escape of HCC mediated by Tregs. |
| Pubmed ID | 31351327 |
| Year | 2019 |
| Title | Long Non-coding RNA FENDRR Acts as a miR-423-5p Spongeto Suppressthe Treg-Mediated Immune Escape of Hepatocellular Carcinoma Cells |
External Links
| Links for FENDRR | GenBank HGNC NONCODE |
| Links for Hepatocellular Carcinoma | OMIM COSMIC |