Basic Information
| LncRNA/CircRNA Name | FENDRR |
| Synonyms | NA |
| Region | GRCh38_16:86474529-86509099 |
| Ensemble | ENSG00000268388 |
| Refseq | NR_033925 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | doxorubicin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | NSCLC tissues,lung cancer cell lines(NCIeH460, PC9, NCIeH292, NCIeH1975, A549, NCIeH1299 )normal lung epithelial cell line (BEAS2B) |
| Expression Pattern | down-regulated |
| Function Description | we focused on FENDRR roles in NSCLC cell stemness. We found that lncRNA FENDRR expression was significantly decreased in lung cancer tissues and cells, especially in NSCLC cells. Previous studies have indicated that lncRNA FENDRR could suppress tumor progression through ceRNA mechanisms, like FENDRR could inhibit gastric cancer cell malignant activity via acting as a ceRNA to sponge miR-214-3p |
| Pubmed ID | 30981768 |
| Year | 2019 |
| Title | Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR. |
External Links
| Links for FENDRR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |