Basic Information
| LncRNA/CircRNA Name | FAS-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_028371 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast cancer tissues,cell lines(MDA-MB-231, MDA-MB-453, MDA-MB-468, T-47D,MCF-7, ZR-75,SK-BR-3 ,MCF-10A) |
| Expression Pattern | down-regulated |
| Function Description | We assessed expression of FAS-anti sense 1 (FAS-AS1), Taurine Upregulated 1 (TUG1), OPA-interacting protein 5-AS1 (OIP5 -AS1), nuclear-enriched abundant transcript 1 (NEAT1),and highly upregulated in liver cancer (HULC) in breast tumor tissues and adjacent noncancerous tissues (ANCTs). TUG1 was downregulated in tumoral tissues.We demonstrated no significant difference in FAS-AS1, OIP5-AS1, NEAT1, or HULC expression levels between tumoral tissues and ANCTs. Zhou et al18 have shown downregulation of FAS-AS1 expression in breast cancer tissue and cell lines compared with ANCTs and normal breast cells. |
| Pubmed ID | 30957286 |
| Year | 2019 |
| Title | Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics. |
External Links
| Links for FAS-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |