Basic Information
| LncRNA/CircRNA Name | FAM83H-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:123201172-123202743 |
| Ensemble | ENSG00000204949 |
| Refseq | NR_024479 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Western blot etc. |
| Sample | glioma tissues, cell line (U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | FAM83H-AS1 was upregulated in glioma tissues and cell lines and high level of FAM83H-AS1 was associated with poor prognosis of glioma. Loss-of-function assays demonstrated that silenced FAM83H-AS1 obviously suppressed cell proliferation via regulating the cell-cycle distribution and cell apoptosis rate, and mechanistic experiments revealed that FAM83H-AS1 could epidemically silence CDKN1A expression through recruiting EZH2 to the promoter of CDKN1A, thereby influencing the cell cycle and proliferation. Moreover, the the Kaplan-Meier method (log-rank test) was used to analyze the correlation between FAM83HAS1 expression and overall survival of all patients and we found that high level of FAM83H??S1 was associated with poor prognosis ( p < 0.001, log-rank test). |
| Pubmed ID | 29870057 |
| Year | 2018 |
| Title | Long noncoding RNA FAM83H-AS1 exerts an oncogenic role in glioma through epigenetically silencing CDKN1A (p21). |
External Links
| Links for FAM83H-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |