Basic Information
| LncRNA/CircRNA Name | FAM83H-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:123201172-123202743 |
| Ensemble | ENSG00000204949 |
| Refseq | NR_024479 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, etc. |
| Sample | bladder cancer tissue, bladder cancer cell lines (RT4, T24, and J82) and a human normal bladder epithelial cell line (SV-HUC-1) |
| Expression Pattern | up-regulated |
| Function Description | the expression of FAM83H AS1 was obviously elevated in bladder cancer tissue samples and bladder cancer cell lines compared with adjacent normal tissue samples and normal bladder epithelial cell lines, respectively. In addition, high expression of FAM83H AS1 was associated with advanced clinical stage and the presence of muscularis invasion and served as an independent poor prognostic factor for overall survival in patients with bladder cancer. The loss of function study showed that silencing FAM83H AS1 expression suppressed cell proliferation, migration, and invasion and induced cycle arrest at G0/G1 phase. |
| Pubmed ID | 30537032 |
| Year | 2018 |
| Title | FAM83H-AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer |
External Links
| Links for FAM83H-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |