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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability	m6A	Recurrence

Cancer&Entry Information

Cancer Name	nasopharyngeal cancer
ICD-0-3	C11
Methods	Microarray, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP
Sample	NPC cell lines (CNE-1, CNE-2, HONE-1, SUNE-1, HNE-1, 5-8F, 6-10B, C666-1 and HK-1), NPC cell lines (S18 and S26) , The human immortalized nasopharyngeal epithelial cell lines (NP69 and N2Tert) , NPC and normal nasopharynx tissues.
Expression Pattern	up-regulated
Function Description	we identified 384 dysregulated lncRNAs, of which FAM225A was one of the most up-regulated lncRNAs in NPC. FAM225A significantly associated with poor survival in NPC. N(6)-methyladenosine (m6A) was highly enriched within FAM225A and enhanced its RNA stability. FAM225A functioned as an oncogenic lncRNA that promoted NPC cell proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, FAM225A functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin ?3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion.
Pubmed ID	31331909
Year	2019
Title	Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3

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