Basic Information
| LncRNA/CircRNA Name | FAM224A |
| Synonyms | NA |
| Region | GRCh38_Y:18326253-18353210 |
| Ensemble | ENSG00000233522 |
| Refseq | NR_002161 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , RIP , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | glioma specimens,normal brain tissues (NBTs),Normal human astrocyte (NHA) cells ,human glioma U87, U251 and HEK293T cells |
| Expression Pattern | up-regulated |
| Function Description | A1CF was upregulated and functioned as an oncogene via stabilizing and increasing FAM224A expression; moreover, high A1CF and FAM224A expression levels indicated a poorer prognosis for glioma patients.Inhibition of A1CF significantly restrained cell proliferation, migration and invasion, and promoted apoptosis by upregulating miR-590-3p in a FAM224A-dependent manner. FAM224A was a molecular sponge of miR-590-3p and they were in an RNA-induced silencing complex. ZNF143 was upregulated in glioma tissues and cell lines.ASAP3 and MYB were transcriptionally activated by ZNF143, and importantly, ZNF143 could directly target the promoter of FAM224A and stimulate its expression, collectively forming a positive feedback loop. |
| Pubmed ID | 31186064 |
| Year | 2019 |
| Title | Inhibition of the Aberrant A1CF-FAM224A-miR-590-3p-ZNF143 Positive Feedback Loop Attenuated Malignant Biological Behaviors of Glioma Cells |
External Links
| Links for FAM224A | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |