Basic Information
| LncRNA/CircRNA Name | FAM201A |
| Synonyms | NA |
| Region | GRCh38_9:38620474-38624990 |
| Ensemble | ENSG00000204860 |
| Refseq | NR_027294 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi |
| Sample | The NSCLC cell line A549 and SK-MES-1, NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | FAM201A was significantly upregulated in tissues obtained from NSCLC patients resistant to radiotherapy. Increased FAM201A expression was strongly associated with radioresistance and inferior survival in NSCLC, as demonstrated by clinical data. The silence of FAM201A could inhibit cell proliferation and further cell apoptosis of NSCLC cells under X-ray irradiation both in vitro and in vivo. Moreover, by competitively targeting miR-370, FAM201A elevated the epidermal growth factor receptor (EGFR) and the hypoxia-inducible factor 1alpha (HIF-1?) levels. After FAM201A knockdown, EGFR and HIF-1? were repressed with enhanced radiosensitivity. |
| Pubmed ID | 31298332 |
| Year | 2019 |
| Title | Long noncoding RNA FAM201A involves in radioresistance of non-small-cell lung cancer by enhancing EGFR expression via miR-370 |
External Links
| Links for FAM201A | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |