Basic Information
| LncRNA/CircRNA Name | FALEC |
| Synonyms | FALEC, FAL1, LINC00568, ncRNA-a1 |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP |
| Sample | melanoma tissues, cell lines (HEMn, M21, B16, MEL-RM) |
| Expression Pattern | up-regulated |
| Function Description | FALEC was more highly expressed in melanoma tissues and cell lines than in non-neoplastic nevi tissues and normal cell lines.silenced FALEC suppressed the proliferation of melanoma cells, resulted in cell cycle arrest, and induced apoptosis.FALEC boosted melanoma progression via epigenetically repressing p21 through recruiting EZH2 to the promoter of p21.FALEC acted as an oncogene in melanoma and had the potential to be a prognostic biomarker and therapeutic target for melanoma. |
| Pubmed ID | 29196104 |
| Year | 2017 |
| Title | Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21. |
External Links
| Links for FALEC | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |