Detail

Basic Information

LncRNA/CircRNA Name	FAL1
Synonyms	FALEC, FAL1, LINC00568, ncRNA-a1
Region	GRCh38_1:150515757-150518032
Ensemble	ENSG00000228126
Refseq	NR_051960

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	esophageal squamous cell carcinoma
ICD-0-3	NA
Methods	qPCR, Western blot, etc.
Sample	ESCC tissues, Human esophageal cancer cell lines KYSE450 and EC9706,Human normal esophagus epithelial cell line Het-1A
Expression Pattern	up-regulated
Function Description	FAL1 was associated with esophageal cancer cell survival by regulating mitochondrial fission. First, we found that the expression of the mitochondrial fission protein dynamin-related protein 1 (DRP1) was significantly reduced, but the expression of the mitochondrial fusion protein mitofusin 1 (Mfn1) was increased in ESCC tissues and esophageal cancer cell lines as compared with adjacent normal tissues and a normal esophagus epithelial cell line. In addition, we found that reduced expression of DRP1 in the esophageal cancer cell lines KYSE450 and EC9706 cells was associated with increased expression of FAL1. Inhibition of FAL1 promoted mitochondrial fission and mitochondrial dysfunction in KYSE450 and EC9706 cells mediated by DRP1. Silencing of DRP1 abolished FAL1-induced apoptosis through a mitochondrialdependent pathway.
Pubmed ID	30501006
Year	2018
Title	Focally Amplified lncRNA on Chromosome 1 Regulates Apoptosis of Esophageal Cancer Cells via DRP1 and Mitochondrial Dynamics

External Links

Links for FAL1	GenBank HGNC NONCODE
Links for esophageal squamous cell carcinoma	OMIM COSMIC