Basic Information
| LncRNA/CircRNA Name | FAL1 |
| Synonyms | FALEC, FAL1, LINC00568, ncRNA-a1 |
| Region | GRCh38_1:150515757-150518032 |
| Ensemble | ENSG00000228126 |
| Refseq | NR_051960 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Luciferase reporter assay, ChIP, Western blot |
| Sample | esophageal cancer tissues, cell lines( Eca109, KYSE150, Eca9706, Kyse30, TE-1 ) |
| Expression Pattern | up-regulated |
| Function Description | FAL1 was significantly up-regulated in EC tissues and human EC cell lines. Overexpression of FAL1 promoted cell proliferation, invasion ability, and cell cycle, but it inhibited cell apoptosis in EC cell lines. |
| Pubmed ID | 30178844 |
| Year | 2018 |
| Title | Long non-coding RNA FAL1 regulated cell proliferation through Akt pathway via targeting PDK1 in esophageal cancer cells. |
External Links
| Links for FAL1 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |