Basic Information
| LncRNA/CircRNA Name | F11-AS1 |
| Synonyms | F11-antisense 1 |
| Region | GRCh38_4:186286094-186500997 |
| Ensemble | ENSG00000251165 |
| Refseq | NR_033901 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-qPCR, RIP, Western blot analysis, Dual luciferase reporter assay |
| Sample | HCC tissues,normal liver HL-7702 cell line, HCC cell lines (Huh7, HepG2, HepG2.2.15 and SMMC-7721) and HEK-293T cell line |
| Expression Pattern | down-regulated |
| Function Description | Poor expression of lncRNA F11-AS1 was correlated with poor prognosis in patients with HBV-related HCC, and its down-regulation was caused by the HBx protein. lncRNA F11-AS1 was proved to up-regulate the NR1I3 expression by binding to miR-211-5p. Overexpression of lncRNA F11-AS1 reduced the proliferation, migration and invasion, yet induced apoptosis of HepG2.2.15 cells in vitro, which could be abolished by overexpression of miR-211-5p. Additionally, either lncRNA F11-AS1 overexpression or miR-211-5p inhibition attenuated the tumour growth and metastasis capacity of HepG2.2.15 cells in vivo. |
| Pubmed ID | 31880390 |
| Year | 2020 |
| Title | Long Non-Coding RNA F11-AS1 Inhibits HBV-related Hepatocellular Carcinoma Progression by Regulating NR1I3 via Binding to microRNA-211-5p |
External Links
| Links for F11-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |