Basic Information
| LncRNA/CircRNA Name | EWSAT1 |
| Synonyms | EWSAT1, LINC00277, NCRNA00277, TMEM84 |
| Region | GRCh38_15:69072926-69095820 |
| Ensemble | ENSG00000212766 |
| Refseq | NR_026949 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, RIP, Luciferase reporter assay etc. |
| Sample | cell lines (HOS, MG63 and HOS) |
| Expression Pattern | up-regulated |
| Function Description | EWSAT1 enhanced OS cell proliferation, migration, and invasion. Further mechanistic studies found that EWSAT1 positively regulated lncRNA MEG3 expression in the transcriptional level. Finally, we observed that EWSAT1 facilitates OS cell growth and metastasis through regulation of MEG3 |
| Pubmed ID | 27860482 |
| Year | 2016 |
| Title | Long Noncoding RNA EWSAT1 Promotes Osteosarcoma Cell Growth and Metastasis Through Suppression of MEG3 Expression. |
External Links
| Links for EWSAT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |