Basic Information
| LncRNA/CircRNA Name | EWSAT1 |
| Synonyms | NA |
| Region | GRCh38_15:69072926-69095820 |
| Ensemble | ENSG00000212766 |
| Refseq | NR_026949 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | isoflavone calycosin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot |
| Sample | nasopharyngeal cancer cell lines (CNE1, CNE2, and C666-1) |
| Expression Pattern | up-regulated |
| Function Description | We also verified that EWSAT1 was highly expressed in NPC cells. At the same time, we found that calycosin inhibited the growth of NPC cell lines. To further determine whether the effect of calycosin on NPC cells was related to EWSAT1, we used NPC cells with different concentrations of calycosin and found that the expression of EWSAT1 decreased significantly with increasing concentrations of calycosin and that the expression of downstream factors and pathways were also affected. It was demonstrated that calycosin affected NPC cell growth by regulating EWSAT1 and its downstream pathway. In addition, we overexpressed EWSAT1 and found that the increased expression of EWSAT1 weakened the growth inhibitory effect of calycosin on NPC cells. |
| Pubmed ID | 29966979 |
| Year | 2018 |
| Title | Calycosin Inhibits Nasopharyngeal Carcinoma Cells by Influencing EWSAT1 Expression to Regulate the TRAF6-related Pathways |
External Links
| Links for EWSAT1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |