Basic Information
| LncRNA/CircRNA Name | EWS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | osteosarcoma tissue, cell lines( MG63 ) |
| Expression Pattern | up-regulated |
| Function Description | EWS and Sox2 were highly expressed in osteosarcoma tissue samples. In addition, the expression of EWS was positively associated with Sox2 level. We conducted a series of functional assays and observed that Sox2 overexpression could significantly overturned the enhancement of cell proliferation and the decline of cell apoptosis induced by EWS knockdown in osteosarcoma. Moreover, we found a key upstream regulatory gene of Sox2: miR-199a-5p. |
| Pubmed ID | 32236759 |
| Year | 2020 |
| Title | EWS Promotes Cell Proliferation and Inhibits Cell Apoptosis by Regulating miR-199a-5p/Sox2 Axis in Osteosarcoma |
External Links
| Links for EWS | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |