Basic Information
| LncRNA/CircRNA Name | ESCCAL-1 |
| Synonyms | CASC9, ESCCAL-1, ESSCAL1, LINC00981 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, RNAi etc. |
| Sample | primary ESCC tumors |
| Expression Pattern | up-regulated |
| Function Description | LncRNA ESCCAL-1 is such an example as a predicted novel onco-lncRNA, and it is overexpressed in 65% of an independent ESCC patient cohort. More over, knockdown of ESCCAL-1 expression increases esophageal cancer cell apoptosis and reduces the invasion in vitro. |
| Pubmed ID | 25885227 |
| Year | 2015 |
| Title | Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma. |
External Links
| Links for ESCCAL-1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |