Basic Information
| LncRNA/CircRNA Name | EPIC1 |
| Synonyms | Lnc-EPIC1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP |
| Sample | lung cancer tissues, cell lines(H460, H1299, A549) |
| Expression Pattern | up-regulated |
| Function Description | We show that Lnc-EPIC1 expression is significantly higher in established/primary human lung cancer cells than that in human lung epithelial cells. Silencing of Lnc-EPIC1 by targeted siRNA significantly inhibited human lung cancer cell growth, survival and proliferation, whiling inducing G1-S cell cycle arrest and cell apoptosis. |
| Pubmed ID | 30029875 |
| Year | 2018 |
| Title | Long Non-Coding RNA EPIC1 Promotes Human Lung Cancer Cell Growth. |
External Links
| Links for EPIC1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |