Basic Information
| LncRNA/CircRNA Name | EPIC1 |
| Synonyms | ENSG00000224271, Lnc-EPIC1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blotting, RIP |
| Sample | PC tissues,pancreatic cells (HPDE) and PC cells (SW1990 and HPAFII) |
| Expression Pattern | up-regulated |
| Function Description | the expression of the lncRNA EPIC1 (Lnc-EPIC1) is high in PC and closely related to tumor size, TNM staging and lymph node metastasis status. Silencing Lnc-EPIC1 by siRNA targeting could significantly inhibit the cell growth and colony formation ability of PC cells and induced G1/S cell cycle arrest and apoptosis in PC cells. Lnc-EPIC1-specific siRNAs could downregulate the expression of cyclins and CDKs, such as CDC20, CDK4 and Cyclin A1. |
| Pubmed ID | 31810603 |
| Year | 2020 |
| Title | Long Noncoding RNA EPIC1 Interacts With YAP1 to Regulate the Cell Cycle and Promote the Growth of Pancreatic Cancer Cells |
External Links
| Links for EPIC1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |