Basic Information
| LncRNA/CircRNA Name | EPB41L4A-AS2 |
| Synonyms | NA |
| Region | GRCh38_5:112419583-112420978 |
| Ensemble | ENSG00000278921 |
| Refseq | NA |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot |
| Sample | HCC tissues, cell lines (SMMC-7721, QGY-7703, QSG-7701) |
| Expression Pattern | down-regulated |
| Function Description | we have identified a novel lncRNA EPB41L4A-AS2, which is significantly downregulated both in HCC cells and tissues, and plays a negative regulatory role in HCC proliferation and invasion. Mechanistically, cytoplasmic lncRNA EPB41L4A-AS2 functions as an efficient miR-301a-5p sponge, thereby release the expression inhibition of forkhead box L1 (FOXL1). |
| Pubmed ID | 30971290 |
| Year | 2019 |
| Title | Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. |
External Links
| Links for EPB41L4A-AS2 | GenBank HGNC Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |