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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	head and neck squamous cell carcinoma
ICD-0-3	C76.0
Methods	RNA-seq, Microarray, qPCR, Western blot
Sample	NPC cell line (CNE1)
Expression Pattern	down-regulated
Function Description	The relationship of EPB41L4A-AS2 with the clinicopathological features and prognosis of HNSCC patients was evaluated.EPB41L4A-AS2 may be involved in processes associated with the tumor-associated signaling pathway, especially the TGF-B signaling pathway. Low EPB41L4A-AS2 expression was determined,and overexpression of this gene inhibited cell migration and invasion in the EMT model. Moreover, EPB41L4A-AS2 suppressed TGFBR1 expression.A major mechanism of lncRNAs in regulating gene expression involves the interaction with Polycomb repressive complex 2 (PRC2), which catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3) to repress the transcription of specific genes. Considering that the promoter region of TGFBR1 is rich in methylation, we hypothesized that EPB41L4A-AS2 plays a role in inducing the methylation of the TGFBR1 promoter. Competing endogenous RNA (ceRNA) is currently under intense study as a novel mechanism for lncRNA functions, which indicates that RNA transcripts communicate with one another by miRNA response elements.
Pubmed ID	29490660
Year	2018
Title	Identification and validation a TGF-B-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method.

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