Basic Information
| LncRNA/CircRNA Name | ENST457720 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qRT-PCR, Western blot, in vitro knockdown |
| Sample | NSCLC cell lines (NCI-H1975 (EGFR mutations: L858R+T790M), A549 (wild-type EGFR) and SK-MES- 3 1 (exon 19 deletion+T790M)) |
| Expression Pattern | up-regulated |
| Function Description | Higher ENST457720 expression was associated with larger tumor sizes, lymph node metastasis and advanced TNM stage.ENST457720 silencing suppressed NSCLC cell proliferation in vitro and in vivo. Moreover, ENST457720 knockdown inhibited NSCLC invasion and reversed the epithelial-to-mesenchymal transition. ENST457720 promoted NSCLC proliferation and invasion, which may be a novel potential therapeutic target for NSCLC. |
| Pubmed ID | 29495976 |
| Year | 2018 |
| Title | Knockdown of Long noncoding RNA ENST457720 inhibits proliferation of non-small cell lung cancer cells in vitro and in vivo. |
External Links
| Links for ENST457720 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |