Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc |
| Sample | cell lines (Nthy-ori3-1 K-1, TPC-1, SW579, FTC133,XTC-1), FTC tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | Expression of AFAP1-AS1 was increased in thyroid cancer tissues. Down-regulation of AFAP1-AS1 could suppress growth of thyroid cancer cells. Knockdown of AFAP1-AS1 induced apoptosis in thyroid cancer. Decreased cell migration in thyroid cancer as a result of down-regulation of AFAP1-AS1. |
| Pubmed ID | 29331858 |
| Year | 2018 |
| Title | Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor growth, promotes apoptosis and decreases metastasis in thyroid cancer. |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |