Basic Information
| LncRNA/CircRNA Name | ENST00000515084 |
| Synonyms | CASC22, LINC01373, LincRNA-ENST00000515084, TCONS_00024290 |
| Region | GRCh38_16:52258564-52280638 |
| Ensemble | ENSG00000260887 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay, Cell viability assay, Transient transfection etc. |
| Sample | cell lines (MCF-7 and Bcap-37) |
| Expression Pattern | up-regulated |
| Function Description | We found that the C allele of the rs12325489C>T polymorphism in the exonic regions of lincRNA-ENST00000515084 was associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype. Biochemical analysis demonstrated that the C to T base change at rs12325489C>T disrupts the binding site for miRNA-370, thereby influencing the transcriptional activity of lincRNA-ENST00000515084 in vitro and in vivo, and affecting cell proliferation and tumor growth. |
| Pubmed ID | 24879036 |
| Year | 2014 |
| Title | A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses. |
External Links
| Links for ENST00000515084 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |