Basic Information
| LncRNA/CircRNA Name | ENST00000447565 |
| Synonyms | Lnc-LIF-AS |
| Region | GRCh38_22:30239194-30240538 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Microarray hybridization etc. |
| Sample | cervical tissues, cell lines (SiHa and ME-180) |
| Expression Pattern | down-regulated |
| Function Description | ENST00000422259, ENST00000447565 (Lnc-LIF-AS) and ENST00000469965, together with their related antisense mRNA DPYD (dihydropyrimidine dehydrogenase, a pyrimidine catabolic pathway gene), LIF (leukemia inhibitor factor) and FLNC (filamin C) were all notably differentially expressed in both ?Np63a overexpression cells and knockdown cells.An inverse interaction of LIF and ?Np63a expression was as well validated in clinical samples of cervical cancer, and high level of LIF in cervical cancers was related with poor patient survival. |
| Pubmed ID | 28391028 |
| Year | 2017 |
| Title | LncRNA expression profile of ?Np63a in cervical squamous cancers and its suppressive effects on LIF expression. |
External Links
| Links for ENST00000447565 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |