Basic Information
| LncRNA/CircRNA Name | ENST00000434223 |
| Synonyms | Lnc ENST |
| Region | GRCh38_15:38069481-38072959 |
| Ensemble | ENSG00000236914 |
| Refseq | NR_147199 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cancer |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | renal cancer tissues, ccRCC-derived cell lines (786-O and ACHN) and normal human proximal tubular epithelial cell line (HK-2) |
| Expression Pattern | up-regulated |
| Function Description | The expressions of Wnt2b and ?-catenin were significantly increased in renal carcinoma, while E-cadherin was markedly down-regulated. Lowly expressed ENST00000434223 was involved in the poor prognosis of patients with renal cancer. In addition, down-regulating ENST00000434223 could enhance the viability, metastasis and invasiveness of renal cancer cells. However, overexpressing ENST00000434223 remarkably weakened the above cell functions. At the same time, interference or overexpression of ENST00000434223 could affect the expression level of proteins related to the Wnt/?-catenin signal pathway. CONCLUSIONS: LncRNA ENST00000434223 inhibits the progression of renal cancer through the Wnt/shell-catenin signal pathway. |
| Pubmed ID | 31486486 |
| Year | 2019 |
| Title | Long non-coding RNA ENST00000434223 inhibits the progression of renal cancer through Wnt/hygro-catenin signaling pathway |
External Links
| Links for ENST00000434223 | GenBank HGNC NONCODE |
| Links for renal cancer | OMIM COSMIC |