Basic Information
| LncRNA/CircRNA Name | ENST00000426615 |
| Synonyms | HAGLROS |
| Region | GRCh38_2:176177717-176179008 |
| Ensemble | ENSG00000226363 |
| Refseq | NR_110457 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Cell viability assay, EDU formation assay etc. |
| Sample | PTC tissues, cell lines (TPC-1, B-CPAP) |
| Expression Pattern | up-regulated |
| Function Description | CCK-8 assay, colony formation assay and EdU assay revealed that lncRNAs (ENST00000537266 and ENST00000426615) could inhibit cell proliferation. Cell cycle analysis showed that cell proportion was statistically significant increased in G1 phase and decreased in S phase and G2 phase in Si-266 transfected TPC-1 cells. In addition, a noteworthy increase of cell proportion in G1 phase accompanied by a decrease in S phase and unchanged G2 phase in Si-615 transfected TPC-1 cells were also observed. Meanwhile, transwell and scratch assay showed that ENST00000426615 could inhibit the cell motility while ENST00000537266 could not. |
| Pubmed ID | 26824456 |
| Year | 2016 |
| Title | The Long Non-Coding RNA ENST00000537266 and ENST00000426615 Influence Papillary Thyroid Cancer Cell Proliferation and Motility |
External Links
| Links for ENST00000426615 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |