Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , RIP , Western blot , RNAi , in vitro knockdown etc. |
| Sample | lung cancer and adjacent normal tissues , normal human bronchial epithelial cell line (16HBE) and NSCLC cell lines (A549, SPC-A1, PC-9, H1299, and H1975) |
| Expression Pattern | up-regulated |
| Function Description | AFAP1-AS1, recruiting and binding to LSD1, was generally overexpressed in NSCLC tissues.Higher AFAP1-AS1 expression was significantly correlated with larger tumor size, lymph node metastasis, higher TNM stage, and worse overall survival in NSCLC patients.AFAP1-AS1 downregulation inhibited cell migration and induced apoptosis; AFAP1-AS1 knockdown also hindered tumorigenesis in vivo.AFAP1-AS1 repressed HMG box-containing protein 1 (HBP1) expression by recruiting LSD1 to the HBP1 promoter regions in PC-9 and H1975 cells.Furthermore, the oncogenic effect of AFAP1-AS1 is partially dependent on the epigenetic silencing of HBP1. |
| Pubmed ID | 31069893 |
| Year | 2019 |
| Title | Long Noncoding RNA Actin Filament-Associated Protein 1 Antisense RNA 1 Promotes Malignant Phenotype Through Binding With Lysine-Specific Demethylase 1 and Repressing HMG Box-Containing Protein 1 in Non-Small-Cell Lung Cancer |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |