Basic Information
| LncRNA/CircRNA Name | ELFN1-AS1 |
| Synonyms | ELFN1 antisense RNA 1 |
| Region | GRCh38_7:1738630-1742291 |
| Ensemble | ENSG00000236081 |
| Refseq | NR_120508 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Microarray, Luciferase reporter assay, RIP, Western blotting |
| Sample | CRC tissues,colorectal cell (FHC) and CRC cells 72 (HCT116, SW620, HT29, LoVo) |
| Expression Pattern | up-regulated |
| Function Description | ELFN1-AS1 expression was elevated in CRC tissues and cells, and ELFN1-AS1 upregulation was correlated with poor prognosis of CRC sufferers.ELFN1-AS1 exerted pro-proliferation, anti-apoptosis and pro-migration functions on CRC cells by acting as a sponge of miR-4644 to increase TRIM44 expression at mRNA and protein level. |
| Pubmed ID | 31929141 |
| Year | 2020 |
| Title | ELFN1-AS1 Accelerates the Proliferation and Migration of Colorectal Cancer via Regulation of miR-4644/TRIM44 Axis |
External Links
| Links for ELFN1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |