Basic Information
| LncRNA/CircRNA Name | ELF3-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:202000094-202010353 |
| Ensemble | ENSG00000234678 |
| Refseq | NR_146472 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | RT-qPCR, Western blot |
| Sample | OSCC (cancer) tissues,two OSCC cell lines, SCC090 and SCC25 |
| Expression Pattern | up-regulated |
| Function Description | ELF3-AS1 and glucose transporter 1 (GLUT1) were both upregulated in OSCC tissues, and those two factors were positively correlated. In OSCC cells, ELF3-AS1 overexpression resulted in upregulation, while ELF3-AS1 siRNA silencing caused downregulated expression of GLUT1 and glucose uptake. ELF3-AS1 and GLUT1 overexpression resulted in increased rate of OSCC cells, while ELF3-AS1 and GLUT1 siRNA silencing resulted in decreased proliferation rate of OSCC cells. |
| Pubmed ID | 31686842 |
| Year | 2019 |
| Title | LncRNA ELF3-AS1 Is Involved in the Regulation of Oral Squamous Cell Carcinoma Cell Proliferation by Reprogramming Glucose Metabolism |
External Links
| Links for ELF3-AS1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |