Basic Information
| LncRNA/CircRNA Name | EGOT |
| Synonyms | EGOT, EGO, NCRNA00190 |
| Region | GRCh38_3:4749192-4751590 |
| Ensemble | ENSG00000235947 |
| Refseq | NR_004428 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | breast cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | EGOT expression was lower in breast cancer compared with the adjacent noncancerous tissues, and low levels of EGOT expression were significantly correlated with larger tumor size, more lymph node metastasis, and higher Ki-67 expression. Moreover, patients with low levels of EGOT expression showed significantly worse prognosis for overall survival. Multivariate analysis suggested that low levels of EGOT were a poor independent prognostic predictor for breast cancer patients |
| Pubmed ID | 26159853 |
| Year | 2015 |
| Title | Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer |
External Links
| Links for EGOT | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |