Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | actin filament-associated protein 1-antisense RNA1 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR, Western blot |
| Sample | OSCC tiusses,NOK and SCC25 cells |
| Expression Pattern | up-regulated |
| Function Description | The expression of AFAP1-AS1 was higher in the OSCC tissues than in the NOK cells, and the relative expression of AFAP1-AS1 was higher in the SCC25 cells than in the NOK cells (P<0.001). AFAP1-AS1 expression was associated with the degree of diffe-rentiation, TNM stage, lymphatic metastasis, and poor prognosis of OSCC (P<0.05). Patients with a high expression of AFAP1-AS1 had lower survival rates than those with a low expression of AFAP1-AS1. |
| Pubmed ID | 31875436 |
| Year | 2019 |
| Title | Expression and Functions of Long Non-Coding RNA Actin Filament-Associated Protein 1-antisense RNA1 in Oral Squamous Cell Carcinoma |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |