Basic Information
| LncRNA/CircRNA Name | DUXAP8 |
| Synonyms | NA |
| Region | GRCh38_22:15784959-15829984 |
| Ensemble | ENSG00000206195 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | primary GC tissues, cell lines (SGC7901, BGC823, GSE-1) |
| Expression Pattern | up-regulated |
| Function Description | DUXAP8 was remarkably upregulated in GC. Additionally, a higher level of DUXAP8 expression in GC was significantly associated with greater tumor size, advanced clinical stage, and lymphatic metastasis. Patients with a higher level of DUXAP8 expression had a relatively poor prognosis. Further experiments revealed that knockdown of DUXAP8 significantly inhibited cell proliferation and migration, as documented in the SGC7901 and BGC823 cell lines. Furthermore, RNA immunoprecipitation and chromatin immunoprecipitation assays demonstrated that DUXAP8 could epigenetically suppress the expression of PLEKHO1 by binding to EZH2 and SUZ12 (two key components of PRC2), thus promoting GC development. |
| Pubmed ID | 27507049 |
| Year | 2016 |
| Title | The pseudogene derived long noncoding RNA DUXAP8 promotes gastric cancer cell proliferation and migration via epigenetically silencing PLEKHO1 expression. |
External Links
| Links for DUXAP8 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |