Basic Information
| LncRNA/CircRNA Name | DUXAP8 |
| Synonyms | NA |
| Region | GRCh38_22:15784959-15829984 |
| Ensemble | ENSG00000206195 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RIP, Western blot, other |
| Sample | PDAC tissues and cell lines (AsPC-1, BxPC-3, and PANC-1) |
| Expression Pattern | up-regulated |
| Function Description | High DUXAP8 expression was associated with a larger tumor size, advanced pathological stage and shorter overall survival of pancreatic cancer patients. Moreover, silencing DUXAP8 expression by siRNA or shRNA inhibited pancreatic cancer cell proliferation and promoted apoptosis in vitro and in vivo. Mechanistic analyses indicated that DUXAP8 regulates PC cell proliferation partly through downregulation of tumor suppressor CDKN1A and KLF2 expression. |
| Pubmed ID | 30367681 |
| Year | 2018 |
| Title | DUXAP8, a Pseudogene Derived lncRNA, Promotes Growth of Pancreatic Carcinoma Cells by Epigenetically Silencing CDKN1A and KLF2 |
External Links
| Links for DUXAP8 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |