Basic Information
| LncRNA/CircRNA Name | DUXAP8 |
| Synonyms | NA |
| Region | GRCh38_22:15784959-15829984 |
| Ensemble | ENSG00000206195 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , RIP etc. |
| Sample | HCC tissues and normal tissues ,human HCC cell lines and normal cell line |
| Expression Pattern | down-regulated |
| Function Description | Dysregulated DUXAP8, LINC01116, LINC01138, and PCAT6 are significantly associated with HCC patients' poor outcomes. Down-regulation of lncRNA DUXAP8 inhibited HCC cells proliferation and colony formation ability. DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with histone-lysine N-methyltransferase enzyme enhancer of zeste homolog 2. |
| Pubmed ID | 31571902 |
| Year | 2019 |
| Title | Up-regulated Long Non-Coding RNA DUXAP8 Promotes Cell Growth Through Repressing Kr?ppel-like Factor 2 Expression in Human Hepatocellular Carcinom |
External Links
| Links for DUXAP8 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |